Alzheimer’s disease is a neurodegenerative disease that causes severe damage to the brain and kills many neurons, affecting the connections between them. This has an effect on behavioral and cognitive levels, and affects, among other things, memory.
Alzheimer’s disease is a type of cortical dementia and is one of the most common and well-known. Usually, the disease progresses gradually, this is why early detection and diagnosis is essential. Treatment in the early stages of the disease can relieve symptoms and slow their progression.
Proteins involved in Alzheimer’s disease
The exact cause of this disease is still unknown today, although some changes are observed in the brains of people suffering from this disease. People with Alzheimer’s disease have a high number of neurofibrillary tangles and beta-amyloid plaques.
Scientific data suggests that there are malformations in two proteins found in the brain, tau proteins and beta-amyloid. According to a group of researchers from the Montreal Neurological Institute, these proteins spread through the brain like a plague and are linked to aging and neurodegenerative diseases like Alzheimer’s disease.
While initial research suggested that the two proteins initially emerge in separate brain regions, a new study published in December 2016 in the Journal Acta Neuropathologica states that both proteins are present in the early stages of the disease and in the brain region itself, Suggesting that the two contribute to the onset of the disease and are more connected than previously thought. This research was conducted by the University of Aberdeen.
First symptoms of Alzheimer’s disease
This study therefore concludes that for the first time, the molecules supposedly contribute to the initial disease process, i.e. they are present at very early stages of Alzheimer’s disease. They are found in an area of the brain involved in memory formation and information processing, which could have implications for the development of new drugs, but can also provide important information for the early diagnosis of the disease. .
I … What are the symptoms of early diagnosis? What are the behaviors of people with Alzheimer’s disease in the early stages of the disease?
Below is a list of the first symptoms and characteristic signs of people with early-stage Alzheimer’s disease.
1. Frequent falls
While falls are somewhat common in older people, they are even more common in people with Alzheimer’s disease.. This was found in a study in which 125 adult subjects participated and who were tracked how often they fell or tripped over an eight-month period.
It turns out that when the group of researchers performed brain scan tests, subjects with Alzheimer’s disease fell further. Falls are common in people with this condition due to walking or lack of guidance. Likewise, these people often present with a hyperkinetic disorder., Which makes them more active and move more, increasing the chances of falling.
2. Forget some aspects of the routine
Memory problems are characteristic of Alzheimer’s disease, So that at the early stage of the disease it is possible to detect that the memory of such people is failing. The easiest way to observe it is in functional objects and those that are used daily. For example, the person does not remember where the keys or dirty dishes are stored. He has serious difficulty performing simple tasks that he normally does.
3. Inability to recognize sarcasm
People with Alzheimer’s Disease Don’t Understand SarcasmSo when faced with this situation, they can get extremely serious and take things at face value. A study from the University of California, San Francisco, led by Katherine Rankin, found that patients with Alzheimer’s disease and those with frontotemporal disease did not recognize sarcasm in face-to-face encounters.
The cause appears to be that the posterior hippocampus of the brain is affected by Alzheimer’s disease and is an area where short-term memory is stored, which affects sarcasm.
4. Loss of personal effects
Sand noted that people with Alzheimer’s disease may forget some aspects of the routine, Like not knowing where to store the keys or not remembering whether or not they ate throughout the day. This often causes them to lose their own belongings, not knowing where to put them. It is common for them to even put their things in the wrong place, for example, the clock in the refrigerator.
5. Changes in their social behavior
People with Alzheimer’s Disease exhibit a number of behaviors that make them think something is happening to them. His way of behaving towards his plans is changing or he stops doing the hobbies he loved so much before. The person withdraws more and more from social life and may sleep more or spend more time watching TV instead of socializing with other people.
6. Difficulty solving problems
It is common for patients to have difficulty solving problems. In fact, they have difficulty performing mathematical operations or following a series of directions. For example, it would be very difficult for them to be able to follow a simple recipe.
7. Mood swings
Mood swings are common in people with Alzheimer’s disease, Which can become very problematic and even confrontational at an advanced stage. In fact, their personalities change dramatically as the disease progresses, and family members are the ones who feel this behavior the most.
Anxiety, sadness, fear or frustration are emotions that these subjects can often suffer from. They can easily get angry at home and in places they are outside of their environment.
8. Confusion over time and place
People with this condition may be confused about when and where. In other words, they can feel disoriented and lose with some ease. This causes them serious problems and, as noted above, disorientation also causes these people to fall further.
9. Loss of common sense
A person’s judgment is his opinions and decisions. People with Alzheimer’s disease may see this ability diminished, causing them to pay less attention to their personal care or make decisions that are incomprehensible and far from common sense.
For example, giving a lot of money to a phone salesperson who calls you on your cell phone to make you an offer. These decisions may seem strange and irresponsible to other mortals, but not to them.
10. Excessive agitation
It is not uncommon for people with Alzheimer’s disease to feel anxious or agitated.. What causes them to be in constant motion … Restlessness is usually the result of fear, confusion or trying to understand the world which sometimes starts to lack meaning. It also causes the aforementioned mood swings and is a clear sign that the person is changing.
11. Difficulties in communicating
With this disease, the language and communication skills of the affected person significantly decrease. It is very common that even in vocabulary these symptoms can be observed: difficulty finding the right word, saying things with bad names, replacing familiar words with unusual or incorrect words, or calling acquaintances like if they were “that guy”).