METACUALONA (Quaalude): history, effects and uses

METACUALONA, commonly known as “Quaalude”, one of its trade names, is a very popular sedative as a recreational drug in the 1960s and 1970s. References to this drug can be found in films such as “The Wolf of Wall Street” and “Scarface”, as well as in songs by David Bowie or Frank Zappa.

In this article we will talk about the pharmacological properties, history, effects and uses of METACUALONA. Although it has been replaced by other less addictive anxiolytics and is not currently manufactured legally, this drug has played a striking role in the development of pharmacotherapy which deserves to be analyzed.

    What is METACUALONA?

    METACUALONA is a medicine with depressant effects on the nervous system which is classified under the category of hypnotic and sedative drugs, as well as anxiolytics. It is part of the pharmacological class of quinazonlinones.

    Psychotropic anxiolytics and sedatives are used to treat symptoms such as anxiety or insomnia, and some of them have effects that make them vulnerable to physical and psychological addictions. Benzodiazepines are the most widely used today, although azapirones are growing in popularity, especially buspirone.

    The best known trade name of METACUALONA is “Quaalude”, An abbreviation of the words “quiet interlude”, which can be translated as “quiet interlude”. Other nomenclatures referring to this drug include “Mandrax”, “Sopor”, “Malsed” or “renoval”, although these products are no longer legally manufactured in most countries.

    What was it used for?

    From a medical point of view, METACUALONA has been used primarily to treat the physical and psychological symptoms of physiological overactivation, such as anxiety and stress. in particular METACUALONA was previously prescribed for people with insomnia and also as a muscle relaxant.

    However, the fact that METACUALONA is still known today is due to the fact that it was very popular as a recreational drug in nightclubs in Anglo-Saxon countries like the US, UK and Australia. In this way Consumption of Quaalude was associated with hippie and glam rock cultures.

    On the other hand, METACUALONA is also among the sedatives which have gained a bad reputation for its use as ‘date-rape drugs’. Of particular note is the case of comedian Bill Cosby, who, during his testimony at a rape trial, said he used Quaalude to abuse numerous young women.

    History of this drug

    METACUALONA was first synthesized in India in the 1950s for use as an antimalarial drug. It arrived in the UK and the US in the 1960s; it was here that its use became popular not only as an anti-anxiety drug, but also as a recreational drug. It was in the United States that the name “Quaalude” was born.

    Due to the obvious addictive potential of this substance and the frequency of its use for purposes other than doctors, from the 1970s the regulations around METACUALONA began to gradually tighten. the same other more effective and safer sedative drugs were emerging, Such as benzodiazepines and azapirones.

    METACUALONA is currently difficult to obtain in most countries of the world because it has been banned. Some relevant exceptions include South Africa, Mozambique, Zimbabwe, Angola and Zambia, as the use and abuse of METACUALONA (often marketed as Mandrax) is very common in these parts of Africa.

    Elsewhere, although there are products on the black market that contain this drug, in many cases it is mixed with barbiturates, benzodiazepines, opiates (especially codeine) and other substances that have effects. central nervous system depressants.

    If you know in Latin American countries like Mexico, Colombia and Peru there are illegal laboratories who manufacture METACUALONA; the same is true of the United States, Canada, Lebanon and elsewhere.

    Adverse reactions and reactions

    the METACUALONA enhances the activity of the inhibitory neurotransmitter GABA (Gamma-aminobutyric acid), which explains its physiological effects, mainly the reduction of blood and respiratory frequencies, which in turn leads to an intense feeling of mental relaxation, as well as physical.

    Although it was introduced to the market as a substitute for barbiturates with a lower risk of side effects and addiction, it soon became clear that METACUALONA not only it creates a strong dependence and generates a high risk of dependenceBut as a result, stopping regular consumption also caused symptoms of abstinence.

    Overdose of METACUALONA causes excessive depression of the activity of the nervous, respiratory and circulatory systems. This results in signs like muscle hypertension, convulsions, nausea and vomiting, delirium (Acute Confusional Syndrome) and even coma and death.

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