Clexane: Functions and side effects of this drug

Cardiovascular problems are probably with dementia and cancer among the most worrying of the majority of the population, given the importance for our survival that the blood circulates normally in our body and that the heart continues to pump it in the usual way.

And it is a fact that a large proportion of the elderly suffer from some type of heart or circulatory problem.

However, advances in medicine have allowed the development of drugs capable of treating some of these types of pathologies, such as Sintrom or the drug we will be talking about throughout this article: Clexane.

    What is Clexane?

    We call Clexane a type of drug type anticoagulant widely used in the medical field, In response to complex cardiovascular problems that endanger the lives of those who suffer from it.

    As an anticoagulant, its function is to reduce blood clotting, which, although generally positive as it helps stop bleeding in specific cases where this process occurs to a large extent, can make it difficult for blood to pass through and even cause a thunderstorm. Thus, thanks to the anticoagulant, it is possible to maintain the blood circulation in a liquid and fluid manner and to reduce the risk.

    Clexane is a medicine whose active ingredient is enoxaparin sodium, being one of the low molecular weight heparins (Which are derived from unfractionated) which is obtained from the intestines of the pig. It is a drug whose main route of administration is intravenous or subcutaneous, marketed in the form of prepared syringes. It is not applied orally or intramuscularly.

      its functions

      Clexane is a drug widely used in various conditions in which it can save lives, either as a treatment or even as a prevention of certain potentially fatal situations, All related to the cardiovascular system.

      One of the main indications is given in the treatment of deep vein thrombosis, an alteration in which blood clots block one of the veins in the bodyUsually aimed at the extremities, and can have serious consequences (including possible pulmonary embolism).

      Also, not only during treatment but also as prevention in case of high risk or to prevent it from happening again in people who have already suffered from it before.

      It is also used in the treatment of acute coronary syndromes, including certain types of angina pectoris and heart attacks, usually as a preliminary step or in combination with other medicines, as well as in the prevention of relapses. Likewise, has been shown to be effective in preventing possible thrombi in respiratory or heart failure, As well as in people in a coma or who need to lie down (for example in a long recovery) and even to avoid possible clots in the case of patients undergoing hemodialysis.

      It should be noted that Clexane can be used at any age from adulthood, including very advanced ages if necessary. However, there are not enough studies in minors to know if this is a safe drug, being a drug that should only be applied to adults.

      Possible side effects

      This drug has been shown to be very useful and has saved many lives since its discovery, but like all drugs it is not free from risks and side effects.

      First of all, and as with other blood thinners, it should be borne in mind that the fact that blood clotting is prevented from causing bleeding of varying severity in any part of the body.

      Seeds and seemingly simple bumps can bleed or cause internal bruising of great relevance, and it must be necessary to be very careful in this regard. It is the most common secondary symptom. Likewise, hemorrhagic anemia can also occur. Sometimes these hemorrhages can occur in the intestinal, spinal or intracranial level, their danger being much greater.

      The possibility of onset as well as edema, erythema, alopecia dermatitis or even fever has also been observed. It has been observed that in some cases it excessively increases the level of potassium in the blood or even triples the levels of transaminases and other liver enzymes. They are more serious skin necrosis or vasculitis, liver damage or thrombocytopenia which can paradoxically generate thrombosis (which makes it necessary to periodically carry out a platelet count of the subject).

      contraindications

      As we have seen, although very useful, Clexane can also generate dangerous effects, which can endanger certain sections of the population. That is why it has several contraindications.

      One of these contraindications can be found in cases of people who have allergies or hypersensitivity to both this drug and other heparins, as well as to its multiple components. is totally contraindicated in people at high risk of bleeding, Including people who are going to have surgeries or who are going to have punctures, people with ulcers, aneurysms or vascular problems in which the walls of the vessels are more fragile.

      Also in people with heparin-induced thrombocytopenia. People with high levels of potassium in the blood should avoid it, and it is also not recommended in severe renal impairment (with the possible exception of its use in dialysis), as well as extreme caution in patients with hepatic insufficiency.

      Not recommended either, or at least great caution and control is necessary in diabetic patients because of the adrenal changes it can cause. Underweight or obese patients should be monitored as there is an increased risk of bleeding or thrombus. The use of Clexane in people taking other medicines should be consulted. Finally, and as we have indicated above, since there are no data on it, it is contraindicated in children.

      Bibliographical references:

      • Spanish Agency for Medicines and Health Products (2018). Clexane. Technical file. [Online]. Available at: https://cima.aemps.es/cima/pdfs/es/ft/58503/FT_58503.html.pdf.

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