Nolotil (metamizole): uses, characteristics and side effects

Trauma, cuts, inflammation, infections … There are many things that can cause us different types and degrees of physical pain.

While the perception of pain is in principle adaptive in that it lets us know that something is not working well or is causing us harm (being able to try to do something to prevent it), the truth is that it is usually extremely aversive, being something that most people prefer to avoid experiencing.

In addition, pain, when intense, can be very disabling to the point of hindering our functionality, especially when it is due to elements over which we have no direct control or which require a process to be able to heal. or solve. Fortunately, in the course of history, different substances have been discovered and then synthesized which decrease nociception or the perception of pain. One of them is the drug known as Nolotil, What we will talk about in this article.

    What is Nolotil and what is it used for?

    The name Nolotil refers to the trade name of a drug that is relatively common in our country, the main active ingredient is metamizole or dipyrone. The mechanism of action of this drug is not fully understood, although it has been observed to inhibit the synthesis of prostaglandins which contribute to the activation of nociceptors.

    It is a drug whose best-known use is that which comes from its effects as an analgesic, decrease and treat pain from different diseases and disorders. In addition to this, it also has an antipyretic effect, able to reduce fever, and ANTI-SPASMOLYTIC (that is, it also has an effect on reducing muscle spasms and the pain in them. partner). While not technically an anti-inflammatory, in supratherapeutic doses it has been found to be helpful in calming and reducing inflammation, although the dose used for this can lead to toxicity.

    It is available in a wide variety of possible presentations, including the most common: as a capsule to be taken orally. However, it can also be found in bottle form (also for oral use). It also comes as an injectable parenterally (although it should only be used in very specific cases) or even anal as a suppository.

    Nolotil has more potency than others commonly used like paracetamol or ibuprofen, but on the contrary also has more risks and side effects and even toxic which have led to its banning in some countries.

      main indications

      As we said, Nolotil has analgesic, antipyretic, antispasmodic and even in certain doses anti-inflammatory propertiesAnd it can be used to treat a wide variety of disorders.

      The most common is its use in acute pain, especially in the case of surgery or trauma. too much it is used to relieve oncological-type pain (I.e. generated by tumors) or colic and spasms of visceral or muscle origin. Its use at the dental level is not uncommon either.

      Despite its power to reduce fever, it is generally only used when not reduced with other antipyretic drugs. Although it is generally used for headaches or headaches, it is not recommended due to the risks involved.

      Side effects

      Nolotil is a drug which enjoys great popularity and has shown great utility in the treatment of pain caused by various diseases and conditions, but can nevertheless generate a number of side effects and even toxic ones which is worth considering.

      Among the most common, we can find a probable decrease in blood pressure, and can lead to hypotension. Allergic reactions and rashes, gastrointestinal upset and breathing difficulties can also occur.

      More serious and less frequent are the presence of arrhythmias, severe allergic reactions (which can lead to anaphylactic shock), leukopenia or decrease in white blood cells, toxic necrolysis of the skin, Difficulty urinating, inflammation of the kidneys, bleeding in the digestive tract or even the aforementioned blood pressure drops sharply and extremely (which is very dangerous).

      One of the possible side effects of its administration and one of the prohibited causes in countries like the United Kingdom or the United States is agranulocytosis (an alteration in which one of the types of leukocytes or white blood cells is reduced so that the body is much more fragile and can lead to death). Another possible side effect with life-threatening potential could be 1 sepsis or generalized infection, As well as kidney failure.


      In addition to the above side effects and partly based on them, it should be noted that Nolotil also has contraindications or situations in which the appropriateness of its use must be carefully analyzed.

      To begin with, all people who are hypersensitive or allergic to this drug or to others of similar composition, including obviously anyone who has had agranulocytosis as a result of previous applications, should avoid taking Nolotil. Also people with asthma of any kind, Allergic reactions to pain relievers, acute intermittent hepatic porphyria, bone marrow or blood problems, or genetic problems with glucose 6-phosphate dehydrogenase.

      It is also contraindicated during pregnancy and lactation, Both in the mother and in the child. It is also not recommended for people who are very old or have kidney or liver problems, as well as those with already low or unstable blood pressure. Caution is also advised when operating dangerous vehicles or machinery in case of use in high doses, and its consumption should be avoided at the same time as alcohol or other drugs (caution is also in order). in the case of drugs).

      Bibliographical references:

      • Spanish Agency for Medicines and Health Products (2011) Flyer: Information for the user. Nolotil 575 mg hard capsules. Magnetic metamizole. [Online]. Available at:
      • Buitrago-González, TP; Calderón-Ospina, CA and Vallejos-Narváez, A. (2014). Dipirona: Underestimated Benefits or Oversized Risks? Literature review. Catalan Society for Chemical-Pharmaceutical Sciences, 43 (1). Bogota.

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