Urbason (methylprednisolone): what it is, uses and side effects

Inflammation is a very common thing in a large number of injuries and illnesses, whether localized or widespread, and can have a very diverse origin. They occur as a response of the immune system to an injury or infection, as a reaction to the entry into the body of particles that it identifies as harmful without being harmful, so the case of reactions to the allergic or the cause of diseases such as multiple sclerosis.

While most of the inflammations that we will have throughout life will be mild, the truth is that there are also processes in which they can endanger the life of the person, which has generated the need to create drugs capable of stopping the inflammatory process. One of these drugs, relatively well known in the general population, is Urbason. Let’s see what it is and how it works.

    Urbason: What is it?

    He is known as Urbason an a type of anti-inflammatory drug such as a steroid or corticosteroid the main active ingredient is methylprednisolone. Specifically, it is said to be part of the glucocorticoids, which work by reducing the activity of our body’s immune system and reducing the formation of substances involved in inflammatory reactions.

    This drug, of great power and being a corticosteroid of intermediate life, has as main mechanism of action the interaction of its components with the cell membrane to be able to generate a complex which after its entry into the nucleus will contribute to increase or to slow down the synthesis of inflammatory proteins.

    It also changes the metabolism, While inhibiting the action of vitamins such as D (which in turn is linked to decreased calcium levels). It also acts as a vasodilator, decreases glucose utilization in most systems, and increases blood sugar levels. It would act in the same way as cortisone, the stress hormone, produced in the stem

    This drug has several presentations and routes of administration, and can be used orally in tablet form or in an emergency can also be found in injectable form intravenously or intramuscularly.

    It is also important to keep in mind that, and especially when used continuously and in high doses, treatment should never be interrupted all at once because it can cause severe syndromes that can even lead to death.

      main indications

      Urbason is a drug of great potency and utility in the treatment of various ailments, both for the treatment of specific diseases and when immediate treatment and rapid effects are required (in the case of injectables, usually in case of danger of death).

      In general, we are talking about a use focused on the treatment of inflammation and the alterations in which it occurs an excessive or dangerous response of the immune system.

      Among the conditions for which it is prescribed are the treatment of anaphylactic shock, intoxication, adrenal insufficiency, lupus erythematosus or multiple sclerosis. It is also particularly relevant in treatment of severe edema such as brain edema (Used for example in certain traffic accidents) or those of the respiratory tract, as well as in response to the rejection of transplants.

      It is often used as a medicine to help chemotherapy or even radiation therapy work. It is also used in Addison’s disease, in which there is hypofunction of the adrenal glands which can lead to severe insufficiency.

      Other conditions under which it has been found useful are severe asthmatic attacks, COPD, different types of arthritis and rheumatism, anemia and problems such as hematology, urticaria, or inflammatory processes such as hepatitis or optic neuritis.

      Side effects

      As we have said, Urbason, although relatively common in different conditions and alterations, as a corticosteroid which manifests itself as a high potency drug which although it can be very useful and even save lives, can also generate various types of side effects.

      Some of the most common are increased appetite and weight, as well as high blood sugar and increased cholesterol and triglycerides, as well as water retention, hirsutism (hair growth), skin disorders, slower healing and alterations in fat distribution. Other currents are the muscle weakness, dizziness, irregular menstrual cycle, sweating and fatigue.

      It should also be borne in mind that this is a drug that decreases the response of the immune system, which sometimes makes it easier to develop infections and diseases.

      also can cause erectile dysfunction, hormonal problems, growth disturbances, arrhythmias, thrombosis, Convulsions. muscle problems, ulcers or glaucoma. It also promotes osteoporosis, by reducing calcium levels as discussed above.

      Another type of side effects that Urbason can generate are psychological: this drug is one of the steroidal anti-inflammatory drugs or corticosteroids which has a greater propensity to contribute to the appearance of symptoms, in particular as regards concerns mood swings.

      Usually related to the dose used (they are generally considered a little more frequent from 80 mg / day), some of the mental symptoms that may appear these are mania (which is the most common), depression or psychosis, as well as confusional states.

      Its sudden and gradual withdrawal can also have serious consequences, among which we can find pain, breathing problems, loss of appetite, hypotension or hypoglycemia and even adrenocortical insufficiency which can lead to death.

      contraindications

      Using Urbason can be helpful, but not everyone can take it as it can be dangerous for some segments of the population. To begin with, it is contraindicated for anyone who suffers from allergies to this type of drug.

      Likewise, the elevation in blood sugar that produces may result a danger for diabetic patientsThe need to regulate insulin and the drugs used should be taken into account. People with heart disease, patients who are going to have some type of surgery, should also not take it or do it with caution and under medical recommendation.

      It is also contraindicated or at least should be consulted in people with ulcers, infections or diseases such as herpes, glaucoma, liver problems or in case of pregnancy or breastfeeding.

      It is also not recommended (except when needed, such as in a medical emergency) in people with mood disorders or psychotics. If you are taking other medicines, you should consult your doctor about whether or not to use them, as many medicines interact with Urbason.

      Bibliographical references:

      • Spanish Medicines Agency (2017). Urbason 16 mg tablets. [Online]. Available at https://www.aemps.gob.es/cima/dochtml/ft/59123/FichaTecnica_59123.html#4-6-fertilidad-embarazo-y-lactancia.
      • Spanish Medicines Agency (2017). Package leaflet: information for the user Urbason 40 mg powder and solvent for solution for injection. methylprednisolone [Online]. Available at: https://www.aemps.gob.es/cima/pdfs/es/p/34023/34023_p.pdf.
      • Lozano, M., Pelegrín, C. and O’Neill, A. (1988). Effects of drugs for therapeutic use on the psyche. Judges for Democracy.

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